Effects of Dexmedetomidine on the Pharmacokinetics of Dezocine, Midazolam and Its Metabolite 1-Hydroxymidazolam in Beagles by UPLC-MS/MS

OBJECTIVE: We developed and validated a sensitive and reliable UPLC-MS/MS method for simultaneous determination of dezocine (DEZ), midazolam (MDZ) and its metabolite 1-hydroxymidazolam (1-OH-MDZ) in beagle plasma and investigated the effect of dexmedetomidine (DEX) on the pharmacokinetics of DEZ, MD...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Zhou, Wei, Li, Shuang-long, Zhao, Ti, Li, Le, Xing, Wen-bin, Qiu, Xiang-jun, Zhang, Wei
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7342499/
https://ncbi.nlm.nih.gov/pubmed/32753841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S254055
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