Simultaneous Determination of Celecoxib, Dezocine and Dexmedetomidine in Beagle Plasma Using UPLC-MS/MS Method and the Application in Pharmacokinetics

BACKGROUND: An efficient, fast and sensitive ultra high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) method for simultaneous determination of celecoxib (CEL), dezocine (DEZ) and dexmedetomidine (DEX) in beagle plasma were established. METHODS: The beagle dogs plasmawas precipitat...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Hu, Jie, Su, Xin-juan, Si, Hui-Ling, Song, Rui-Xiang, Zhang, Fang, Qiu, Xiang-Jun, Chen, Xing-Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2021
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214532/
https://ncbi.nlm.nih.gov/pubmed/34163139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S314562
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