Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress

Thymocyte egress is a critical determinant of T cell homeostasis and adaptive immunity. Despite the roles of G protein–coupled receptors in thymocyte emigration, the downstream signaling mechanism remains poorly defined. Here, we report the discrete roles for the two branches of mevalonate metabolis...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Du, Xingrong, Zeng, Hu, Liu, Shaofeng, Guy, Cliff, Dhungana, Yogesh, Neale, Geoffrey, Bergo, Martin O., Chi, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041713/
https://ncbi.nlm.nih.gov/pubmed/31722972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190969
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