Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes

Double-positive (DP) thymocytes respond to intrathymic T-cell receptor (TCR) signals by undergoing positive selection and lineage differentiation into single-positive (SP) mature cells. Concomitant with these well-characterized events is the acquisition of a mature T-cell gene expression program cha...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shi, Lewis Zhichang, Saravia, Jordy, Zeng, Hu, Kalupahana, Nishan S., Guy, Clifford S., Neale, Geoffrey, Chi, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224387/
https://ncbi.nlm.nih.gov/pubmed/27994150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617669114
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