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The G2019S Mutation in LRRK2 Imparts Resiliency to Kinase Inhibition
The G2019S mutation in LRRK2 is one of the most common known genetic causes of neurodegeneration and Parkinson disease (PD). LRRK2 mutations are thought to enhance LRRK2 kinase activity. Efficacious small molecule LRRK2 kinase inhibitors with favorable drug properties have recently been developed fo...
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| Publicado no: | Exp Neurol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7041630/ https://ncbi.nlm.nih.gov/pubmed/30048714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2018.07.012 |
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