The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins

The Leucine rich repeat kinase 2 (LRRK2) gene is genetically and biochemically linked to several diseases that involve innate immunity. LRRK2 protein is highly expressed in phagocytic cells of the innate immune system, most notably in myeloid cells capable of mounting potent pro-inflammatory respons...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Moehle, Mark S., Daher, João Paulo Lima, Hull, Travis D., Boddu, Ravindra, Abdelmotilib, Hisham A., Mobley, James, Kannarkat, George T., Tansey, Malú G., West, Andrew B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492391/
https://ncbi.nlm.nih.gov/pubmed/25926623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv157
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