The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins

The Leucine rich repeat kinase 2 (LRRK2) gene is genetically and biochemically linked to several diseases that involve innate immunity. LRRK2 protein is highly expressed in phagocytic cells of the innate immune system, most notably in myeloid cells capable of mounting potent pro-inflammatory respons...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Moehle, Mark S., Daher, João Paulo Lima, Hull, Travis D., Boddu, Ravindra, Abdelmotilib, Hisham A., Mobley, James, Kannarkat, George T., Tansey, Malú G., West, Andrew B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492391/
https://ncbi.nlm.nih.gov/pubmed/25926623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv157
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados