The use of Trichomonas vaginalis purine nucleoside phosphorylase to activate fludarabine in the treatment of solid tumors

Treatment with fludarabine phosphate (9-β-D-arabinofuranosyl-2-F-adenine 5′-phosphate, F-araAMP) leads to regressions and cures of human tumor xenografts that express Escherichia coli purine nucleoside phosphorylase (EcPNP). This occurs despite the fact that fludarabine (F-araA) is a relatively poor...

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Udgivet i:Cancer Chemother Pharmacol
Main Authors: Parker, William B., Allan, Paula W., Waud, William R., Hong, Jeong, Gilbert-Ross, Melissa, Achyut, B. R., Joshi, Disha, Behbahani, Turang, Rab, Regina, Ealick, Steven E., Sorscher, Eric J.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039746/
https://ncbi.nlm.nih.gov/pubmed/31915968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-019-04018-7
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