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Use of E. coli Purine Nucleoside Phosphorylase in the Treatment of Solid Tumors

The selective expression of non-human genes in tumor tissue to activate non-toxic compounds (Gene Directed Prodrug Enzyme Therapy, GDEPT) is a novel strategy designed for killing tumor cells in patients with little or no systemic toxicity. Numerous non-human genes have been evaluated, but none have...

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Detalhes bibliográficos
Publicado no:Curr Pharm Des
Main Authors: Parker, William B., Sorscher, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224313/
https://ncbi.nlm.nih.gov/pubmed/29119917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1381612823666171109101851
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