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Enhanced efficiency of prodrug activation therapy by tumor-selectively replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene
Gene transfer of the E. coli purine nucleoside phosphorylase (PNP) results in potent cytotoxicity after administration of the prodrug fludarabine phosphate (F-araAMP). Here we have tested whether application of this strategy in the context of replication-competent retrovirus (RCR) vectors, which can...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2938767/ https://ncbi.nlm.nih.gov/pubmed/20467451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2010.17 |
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