Enhanced efficiency of prodrug activation therapy by tumor-selectively replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene

Gene transfer of the E. coli purine nucleoside phosphorylase (PNP) results in potent cytotoxicity after administration of the prodrug fludarabine phosphate (F-araAMP). Here we have tested whether application of this strategy in the context of replication-competent retrovirus (RCR) vectors, which can...

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Detalhes bibliográficos
Main Authors: Tai, Chien-Kuo, Wang, Weijun, Lai, Yi-Hui, Logg, Christopher R., Parker, William B., Li, Yu-Fen, Hong, Jeong S., Sorscher, Eric J., Chen, Thomas C., Kasahara, Noriyuki
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938767/
https://ncbi.nlm.nih.gov/pubmed/20467451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2010.17
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