Enhanced efficiency of prodrug activation therapy by tumor-selectively replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene

Gene transfer of the E. coli purine nucleoside phosphorylase (PNP) results in potent cytotoxicity after administration of the prodrug fludarabine phosphate (F-araAMP). Here we have tested whether application of this strategy in the context of replication-competent retrovirus (RCR) vectors, which can...

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Main Authors: Tai, Chien-Kuo, Wang, Weijun, Lai, Yi-Hui, Logg, Christopher R., Parker, William B., Li, Yu-Fen, Hong, Jeong S., Sorscher, Eric J., Chen, Thomas C., Kasahara, Noriyuki
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938767/
https://ncbi.nlm.nih.gov/pubmed/20467451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2010.17
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