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Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase

The use of E. coli purine nucleoside phosphorylase (PNP) to activate prodrugs has demonstrated excellent activity in the treatment of various human tumor xenografts in mice. E. coli PNP cleaves purine nucleoside analogs to generate toxic adenine analogs, which are activated by adenine phosphoribosyl...

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Bibliografiske detaljer
Main Authors: Parker, W B, Allan, P W, Waud, W R, Hong, J S, Sorscher, E J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096718/
https://ncbi.nlm.nih.gov/pubmed/21394111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2011.4
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