Synthesis and Evaluation of the Substrate Activity of C-6 Substituted Purine Ribosides with E. coli Purine Nucleoside Phosphorylase: Palladium Mediated Cross-Coupling of Organozinc Halides with 6-Chloropurine Nucleosides [1]

A series of C-6 alkyl, cycloalkyl, and aryl-9-(β-d-ribofuranosyl)purines were synthesized and their substrate activities with Escherichia coli purine nucleoside phosphorylase (E. coli PNP) were evaluated. (Ph(3)P)(4)Pd-mediated cross-coupling reactions of 6-chloro-9-(2,3,5-tri-O-acetyl-β-d-ribofuran...

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Main Authors: Hassan, Abdalla E. A., Abou-Elkhair, Reham A. I., Riordan, James M., Allan, Paula W., Parker, William B., Khare, Rashmi, Waud, William R., Montgomery, John A., Secrist, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259247/
https://ncbi.nlm.nih.gov/pubmed/22112758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.10.039
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