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In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase

PURPOSE: Systemically administered fludarabine phosphate (F-araAMP) slows growth of human tumor xenografts that express E. coli purine nucleoside phosphorylase (PNP). However, this treatment has been limited by the amount of F-araAMP that can be administered in vivo. The current study was designed t...

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Detalles Bibliográficos
Main Authors: Sorscher, Eric J., Hong, Jeong S., Allan, Paula W., Waud, William R., Parker, William B.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423194/
https://ncbi.nlm.nih.gov/pubmed/22760227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1908-9
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