SNX27–retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis

A variety of metastatic cancer cells use actin-rich membrane protrusions, known as invadopodia, for efficient ECM degradation, which involves trafficking of proteases from intracellular compartments to these structures. Here, we demonstrate that in the metastatic breast cancer cell line MDA-MB-231,...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Sharma, Priyanka, Parveen, Sameena, Shah, Lekha V., Mukherjee, Madhumita, Kalaidzidis, Yannis, Kozielski, Anthony J., Rosato, Roberto, Chang, Jenny C., Datta, Sunando
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039210/
https://ncbi.nlm.nih.gov/pubmed/31820782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201812098
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