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PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly

The tumor suppressor PTEN executes cellular functions predominantly through its phosphatase activity. Here we identified a phosphatase-independent role for PTEN during vesicular trafficking of the glucose transporter GLUT1. PTEN physically interacts with SNX27, a component of the retromer complex th...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Shinde, Swapnil Rohidas, Maddika, Subbareddy
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695913/
https://ncbi.nlm.nih.gov/pubmed/29117568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.053
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