SNX27–retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis

A variety of metastatic cancer cells use actin-rich membrane protrusions, known as invadopodia, for efficient ECM degradation, which involves trafficking of proteases from intracellular compartments to these structures. Here, we demonstrate that in the metastatic breast cancer cell line MDA-MB-231,...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Sharma, Priyanka, Parveen, Sameena, Shah, Lekha V., Mukherjee, Madhumita, Kalaidzidis, Yannis, Kozielski, Anthony J., Rosato, Roberto, Chang, Jenny C., Datta, Sunando
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039210/
https://ncbi.nlm.nih.gov/pubmed/31820782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201812098
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