Population Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Pregnant South African Women with Tuberculosis and HIV

Tuberculosis is an important cause of maternal morbidity, but little is known about the effects of pregnancy on antituberculosis drug concentrations. We developed population pharmacokinetic models to describe drug dispositions of isoniazid, pyrazinamide, and ethambutol in pregnant women with tubercu...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Abdelwahab, Mahmoud Tareq, Leisegang, Rory, Dooley, Kelly E., Mathad, Jyoti S., Wiesner, Lubbe, McIlleron, Helen, Martinson, Neil, Waja, Ziyaad, Letutu, Matebogo, Chaisson, Richard E., Denti, Paolo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038290/
https://ncbi.nlm.nih.gov/pubmed/31844002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01978-19
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