Population Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Pregnant South African Women with Tuberculosis and HIV

Tuberculosis is an important cause of maternal morbidity, but little is known about the effects of pregnancy on antituberculosis drug concentrations. We developed population pharmacokinetic models to describe drug dispositions of isoniazid, pyrazinamide, and ethambutol in pregnant women with tubercu...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Abdelwahab, Mahmoud Tareq, Leisegang, Rory, Dooley, Kelly E., Mathad, Jyoti S., Wiesner, Lubbe, McIlleron, Helen, Martinson, Neil, Waja, Ziyaad, Letutu, Matebogo, Chaisson, Richard E., Denti, Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038290/
https://ncbi.nlm.nih.gov/pubmed/31844002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01978-19
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