Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid

OBJECTIVES: To describe the pharmacokinetics of isoniazid and acetyl-isoniazid in TB/HIV-coinfected patients, and assess the effects of efavirenz co-administration and a 50% increase in the dose of rifampicin on the pharmacokinetic parameters of isoniazid and acetyl-isoniazid. METHODS: TB/HIV-coinfe...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Antimicrob Chemother
Auteurs principaux: Chirehwa, Maxwell T, McIlleron, Helen, Wiesner, Lubbe, Affolabi, Dissou, Bah-Sow, Oumou, Merle, Corinne, Denti, Paolo
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293084/
https://ncbi.nlm.nih.gov/pubmed/30239829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dky378
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