In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model

Nonimmune Aotus monkeys infected with Plasmodium falciparum and Plasmodium vivax were cured of their infections when treated with a single oral dose of 5 mg/kg and 10 mg/kg of the 2-aminomethylphenol, JPC-3210, respectively. Corresponding mean blood elimination half-lives of JPC-3210 were lengthy at...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: McCallum, Fiona J., Birrell, Geoffrey W., Chavchich, Marina, Harris, Ivor, Obaldia, Nicanor, Van Breda, Karin, Heffernan, Gavin D., Jacobus, David P., Shanks, Dennis, Edstein, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038259/
https://ncbi.nlm.nih.gov/pubmed/31843994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01538-19
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