Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

The new 2-aminomethylphenol, JPC-3210, has potent in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, low cytotoxicity, and high in vivo efficacy against murine malaria. Here we report on the pharmacokinetics of JPC-3210 in mice and monkeys and the results of in v...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Birrell, Geoffrey W., Heffernan, Gavin D., Schiehser, Guy A., Anderson, John, Ager, Arba L., Morales, Pablo, MacKenzie, Donna, van Breda, Karin, Chavchich, Marina, Jacobus, Laura R., Shanks, G. Dennis, Jacobus, David P., Edstein, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2018
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913937/
https://ncbi.nlm.nih.gov/pubmed/29311093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01335-17
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