Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

Structure-activity relationship studies of trifluoromethyl-substituted pyridine and pyrimidine analogues of 2-aminomethylphenols (JPC-2997, JPC-3186, and JPC-3210) were conducted for preclinical development for malaria treatment and/or prevention. Of these compounds, JPC-3210 [4-(tert-butyl)-2-((ter...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Chavchich, Marina, Birrell, Geoffrey W., Ager, Arba L., MacKenzie, Donna O., Heffernan, Gavin D., Schiehser, Guy A., Jacobus, Laura R., Shanks, G. Dennis, Jacobus, David P., Edstein, Michael D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Susceptibility
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862471/
https://ncbi.nlm.nih.gov/pubmed/26856849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03066-15
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