An ontogenetic switch drives the positive and negative selection of B cells

Developing B cells can be positively or negatively selected by self-antigens, but the mechanisms that determine these outcomes are incompletely understood. Here, we show that a B cell intrinsic switch between positive and negative selection during ontogeny is determined by a change from Lin28b to le...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Xu, Xijin, Deobagkar-Lele, Mukta, Bull, Katherine R., Crockford, Tanya L., Mead, Adam J., Cribbs, Adam P., Sims, David, Anzilotti, Consuelo, Cornall, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035474/
https://ncbi.nlm.nih.gov/pubmed/32019891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915247117
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