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DLK activation synergizes with mitochondrial dysfunction to downregulate axon survival factors and promote SARM1-dependent axon degeneration

Axon degeneration is a prominent component of many neurological disorders. Identifying cellular pathways that contribute to axon vulnerability may identify new therapeutic strategies for maintenance of neural circuits. Dual Leucine Zipper Kinase (DLK) is an axonal stress response MAP3K that is chron...

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Bibliografische gegevens
Gepubliceerd in:Mol Neurobiol
Hoofdauteurs: Summers, Daniel W., Frey, Erin, Walker, Lauren J, Milbrandt, Jeffrey, DiAntonio, Aaron
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035184/
https://ncbi.nlm.nih.gov/pubmed/31696428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-01796-2
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