A Critical Insulin TCR Contact Residue Selects High-Affinity and Pathogenic Insulin-Specific T Cells

Type 1 diabetes is an autoimmune-mediated disease that culminates in the targeted destruction of insulin-producing β-cells. CD4 responses in NOD mice are dominated by insulin epitope B:9-23 (InsB(9-23)) specificity, and mutation of the key T-cell receptor (TCR) contact residue within the epitope pre...

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Vydáno v:Diabetes
Hlavní autoři: Bettini, Maria, Scavuzzo, Marissa A., Liu, Baoyu, Kolawole, Elizabeth, Guo, Lin, Evavold, Brian D., Borowiak, Malgorzata, Bettini, Matthew L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2020
Témata:
Immunology and Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034183/
https://ncbi.nlm.nih.gov/pubmed/31836691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0821
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