A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery

β-Cell antigen recognition by autoreactive T cells is essential in type 1 diabetes (T1D) pathogenesis. Recently, insulin hybrid peptides (HIPs) were identified as strong agonists for CD4 diabetogenic T cells. Here, using BDC2.5 transgenic and NOD mice, we investigated T-cell recognition of the HIP2....

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Bibliografiska uppgifter
I publikationen:Diabetes
Huvudupphovsmän: Liu, Baoyu, Hood, Jennifer D., Kolawole, Elizabeth M., Woodruff, Derek M., Vignali, Dario A., Bettini, Maria, Evavold, Brian D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Diabetes Association 2020
Ämnen:
Immunology and Transplantation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034185/
https://ncbi.nlm.nih.gov/pubmed/31806623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0399
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