TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential

Autoreactive T cells infiltrating the target organ can possess a broad TCR affinity range. However, the extent to which such biophysical parameters contribute to T cell pathogenic potential remain unclear. In this study, we selected eight InsB(9-23)-specific TCRs cloned from CD4(+) islet-infiltratin...

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Detalhes bibliográficos
Main Authors: Bettini, Maria, Blanchfield, Lori, Castellaw, Ashley, Zhang, Qianxia, Nakayama, Maki, Smeltzer, Matthew P., Zhang, Hui, Hogquist, Kristin A., Evavold, Brian D., Vignali, Dario A. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082738/
https://ncbi.nlm.nih.gov/pubmed/24943217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400043
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