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The diabetogenic mouse MHC class II molecule I-A(g7) is endowed with a switch that modulates TCR affinity
Genetic susceptibility to autoimmunity is frequently associated with specific MHC alleles. Diabetogenic MHC class II molecules, such as human HLA-DQ8 and mouse I-A(g7), typically have a small, uncharged amino acid residue at position 57 of their β chain (β57); this results in the absence of a salt b...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860908/ https://ncbi.nlm.nih.gov/pubmed/20407212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41502 |
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