Low affinity TCRs support regulatory T cell function in autoimmunity

Regulatory T cells utilize a distinct TCR repertoire and are more self-reactive compared to conventional T cells. However, the extent to which TCR affinity regulates the function of self-reactive Tregs is largely unknown. In this study, we utilized a two-TCR model to assess the role of TCR affinity...

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Veröffentlicht in:J Immunol
Hauptverfasser: Sprouse, Maran L., Shevchenko, Ivan, Scavuzzo, Marissa A., Joseph, Faith, Lee, Thomas, Blum, Samuel, Borowiak, Malgorzata, Bettini, Matthew L., Bettini, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962277/
https://ncbi.nlm.nih.gov/pubmed/29282307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700156
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