High self-reactivity drives T-bet and potentiates Treg function in tissue-specific autoimmunity

T cell receptor (TCR) affinity is a critical factor of Treg lineage commitment, but whether self-reactivity is a determining factor in peripheral Treg function remains unknown. Here, we report that a high degree of self-reactivity is crucial for tissue-specific Treg function in autoimmunity. Based o...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Sprouse, Maran L., Scavuzzo, Marissa A., Blum, Samuel, Shevchenko, Ivan, Lee, Thomas, Makedonas, George, Borowiak, Malgorzata, Bettini, Matthew L., Bettini, Maria
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821181/
https://ncbi.nlm.nih.gov/pubmed/29367462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97322
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