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Activation-induced cell death of self-reactive regulatory T cells drives autoimmunity
Activation of self-reactive T cells is a major driver to autoimmunity and is suppressed by mechanisms of regulation. In a humanized model of autoimmune thyroiditis, we investigated the mechanism underlying break of tolerance. Here, we found that a human TCR specific for the self-antigen thyroid pero...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6936679/ https://ncbi.nlm.nih.gov/pubmed/31818938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910281116 |
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