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Ectopic expression of self-antigen drives regulatory T cell development and not deletion of autoimmune T cells
Type 1 Diabetes (T1D) is a T cell-mediated autoimmune disease that is characterized by antigen specific targeting and destruction of insulin producing β cells. While multiple studies have characterized the pathogenic potential of β-cell specific T cells, we have limited mechanistic insight into self...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5605461/ https://ncbi.nlm.nih.gov/pubmed/28835461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700207 |
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