ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis

BACKGROUND: Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet been explored, nor has the mechanism by which arnidiol induces apoptosis been examined in depth. METHODS: MDA-MB-231 ce...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Clin Cancer Res
Main Authors: Hu, Jinjiao, Zhang, Hongwei, Li, Jie, Jiang, Xiuxing, Zhang, Yanhao, Wu, Qin, Shen, liwen, Shi, Jingshan, Gao, Ning
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031977/
https://ncbi.nlm.nih.gov/pubmed/32075676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01545-7
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