Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation

Increased production of fetal hemoglobin (HbF) can ameliorate the severity of sickle cell disease and β-thalassemia(1). BCL11A represses the genes encoding HbF and regulates human hemoglobin switching through variation in its expression during development(2–7). However, the mechanisms underlying the...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Basak, Anindita, Munschauer, Mathias, Lareau, Caleb A., Montbleau, Kara E., Ulirsch, Jacob C., Hartigan, Christina R., Schenone, Monica, Lian, John, Wang, Yaomei, Huang, Yumin, Wu, Xianfang, Gehrke, Lee, Rice, Charles M., An, Xiuli, Christou, Helen A., Mohandas, Narla, Carr, Steven A., Chen, Jane-Jane, Orkin, Stuart H., Lander, Eric S., Sankaran, Vijay G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031047/
https://ncbi.nlm.nih.gov/pubmed/31959994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0568-7
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