Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease.

Von Willebrand factor (VWF), an exceptionally large multimeric plasma glycoprotein, functions to initiate coagulation by agglutinating platelets in the blood stream to sites of vascular injury. This primary hemostatic function is perturbed in type 2 dysfunctional subtypes of von Willebrand disease (...

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Bibliografski detalji
Izdano u:J Mol Biol
Glavni autori: Tischer, Alexander, Brehm, Maria A., Machha, Venkata R., Moon-Tasson, Laurie, Benson, Linda M., Nelton, Katelynn J., Leger, Rachel R., Obser, Tobias, Martinez-Vargas, Marina, Whitten, Steven T., Chen, Dong, Pruthi, Rajiv K., Bergen, H. Robert, Cruz, Miguel A., Schneppenheim, Reinhard, Auton, Matthew
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028320/
https://ncbi.nlm.nih.gov/pubmed/31628947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.09.022
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