Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease.

Von Willebrand factor (VWF), an exceptionally large multimeric plasma glycoprotein, functions to initiate coagulation by agglutinating platelets in the blood stream to sites of vascular injury. This primary hemostatic function is perturbed in type 2 dysfunctional subtypes of von Willebrand disease (...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Tischer, Alexander, Brehm, Maria A., Machha, Venkata R., Moon-Tasson, Laurie, Benson, Linda M., Nelton, Katelynn J., Leger, Rachel R., Obser, Tobias, Martinez-Vargas, Marina, Whitten, Steven T., Chen, Dong, Pruthi, Rajiv K., Bergen, H. Robert, Cruz, Miguel A., Schneppenheim, Reinhard, Auton, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028320/
https://ncbi.nlm.nih.gov/pubmed/31628947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.09.022
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