Misfolding of vWF to Pathologically Disordered Conformations Impacts the Severity of von Willebrand Disease

The primary hemostatic von Willebrand factor (vWF) functions to sequester platelets from rheological blood flow and mediates their adhesion to damaged subendothelium at sites of vascular injury. We have surveyed the effect of 16 disease-causing mutations identified in patients diagnosed with the ble...

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Hlavní autoři: Tischer, Alexander, Madde, Pranathi, Moon-Tasson, Laurie, Auton, Matthew
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2014
Témata:
Proteins and Nucleic Acids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156683/
https://ncbi.nlm.nih.gov/pubmed/25185554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.07.026
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