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Misfolding of vWF to Pathologically Disordered Conformations Impacts the Severity of von Willebrand Disease
The primary hemostatic von Willebrand factor (vWF) functions to sequester platelets from rheological blood flow and mediates their adhesion to damaged subendothelium at sites of vascular injury. We have surveyed the effect of 16 disease-causing mutations identified in patients diagnosed with the ble...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156683/ https://ncbi.nlm.nih.gov/pubmed/25185554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.07.026 |
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