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Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping

Mutation of the cysteines forming the disulfide loop of the platelet GPIbα adhesive A1 domain of von Willebrand factor causes quantitative VWF deficiencies in the blood and von Willebrand disease. We report two cases of transient severe thrombocytopenia induced by DDAVP-treatment. Cys1272Trp and Cys...

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Dettagli Bibliografici
Pubblicato in:J Mol Biol
Autori principali: Tischer, Alexander, Machha, Venkata R., Frontroth, Juan P., Brehm, Maria A., Obser, Tobias, Schneppenheim, Reinhard, Mayne, Leland, Englander, S. Walter, Auton, Matthew
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839150/
https://ncbi.nlm.nih.gov/pubmed/28533135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.05.013
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