Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist

Tramadol is widely used globally and is the second most prescribed opioid in the United States. It treats moderate to severe pain but lethal opioid-induced respiratory depression is uncommon even in large overdose. It is unknown why tramadol spares respiration. Here we show its active metabolite, de...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Zebala, John A., Schuler, Aaron D., Kahn, Stuart J., Maeda, Dean Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2020
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7025522/
https://ncbi.nlm.nih.gov/pubmed/32116679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01680
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