The CYP2C19*2 and CYP2C19*17 Polymorphisms Influence Responses to Clozapine for the Treatment of Schizophrenia

INTRODUCTION: Clozapine (CLZ) is the gold standard drug for treatment-refractory schizophrenia (TRS). However, approximately 30% of patients partially respond to CLZ, defining this subset with super refractory schizophrenia (SRS). Alterations in enzyme activity may affect CLZ responses; the CYP3A4,...

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Detalhes bibliográficos
Publicado no:Neuropsychiatr Dis Treat
Main Authors: Rodrigues-Silva, Christielly, Semedo, Agostinho Tavares, Neri, Hiasmin Franciely da Silva, Vianello, Rosana Pereira, Galaviz-Hernández, Carlos, Sosa-Macías, Martha, de Brito, Rodrigo Bernini, Ghedini, Paulo César
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023876/
https://ncbi.nlm.nih.gov/pubmed/32103962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/NDT.S228103
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