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A structural determinant of mycophenolic acid resistance in eukaryotic inosine 5′‐monophosphate dehydrogenases

Mycophenolic acid (MPA) is a potent natural product inhibitor of fungal and other eukaryotic inosine 5′‐monophosphate dehydrogenases (IMPDHs) originally isolated from spoiled corn silage. MPA is produced by the filamentous fungi Penicillium brevicompactum, which contains two IMPDHs, PbIMPDHA and PbI...

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Vydáno v:Protein Sci
Hlavní autoři: Freedman, Rebecca, Yu, Runhan, Sarkis, Alexander W., Hedstrom, Lizbeth
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7021006/
https://ncbi.nlm.nih.gov/pubmed/31675145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3766
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