High-throughput transcriptome analysis reveals that the loss of Pten activates a novel NKX6-1/RASGRP1 regulatory module to rescue microphthalmia caused by Fgfr2-deficient lenses

FGFR signaling is critical to development and disease pathogenesis, initiating phosphorylation-driven signaling cascades, notably the RAS-RAF-MEK-ERK and PI3K-AKT cascades. PTEN antagonizes FGFR signaling by reducing AKT and ERK activation. Mouse lenses lacking FGFR2 exhibit microphakia and reduced...

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Udgivet i:Hum Genet
Main Authors: Padula, Stephanie L., Anand, Deepti, Hoang, Thanh V., Chaffee, Blake R., Liu, Lin, Liang, Chun, Lachke, Salil A., Robinson, Michael L.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020882/
https://ncbi.nlm.nih.gov/pubmed/31691004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-019-02084-8
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