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Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression

NKX3.1 is the most commonly deleted gene in prostate cancer and a gatekeeper suppressor. NKX3.1 is a growth suppressor, mediator of apoptosis, inducer of antioxidants, and enhancer of DNA repair. PTEN is a ubiquitous tumor suppressor that is often decreased in prostate cancer during tumor progressio...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Res
Hauptverfasser: Bowen, Cai, Ostrowski, Michael C., Leone, Gustavo, Gelmann, Edward P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753942/
https://ncbi.nlm.nih.gov/pubmed/31213464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-4110
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