Increased PD-1+Tim-3+ exhausted T cells in bone marrow may influence the clinical outcome of patients with AML

BACKGROUND: Altered expression of T cell immune inhibitory receptors may result in immunosuppression and associate with the poor prognosis of leukemia patients in which the leukemic bone marrow (BM) microenvironment may contribute to such immunosuppression. We found higher numbers of programmed deat...

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Pubblicato in:Biomark Res
Autori principali: Tan, Jiaxiong, Yu, Zhi, Huang, Jingying, Chen, Youchun, Huang, Shuxin, Yao, Danlin, Xu, Ling, Lu, Yuhong, Chen, Shaohua, Li, Yangqiu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020501/
https://ncbi.nlm.nih.gov/pubmed/32082573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-020-0185-8
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