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Increased PD-1+Tim-3+ exhausted T cells in bone marrow may influence the clinical outcome of patients with AML

BACKGROUND: Altered expression of T cell immune inhibitory receptors may result in immunosuppression and associate with the poor prognosis of leukemia patients in which the leukemic bone marrow (BM) microenvironment may contribute to such immunosuppression. We found higher numbers of programmed deat...

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Publicat a:Biomark Res
Autors principals: Tan, Jiaxiong, Yu, Zhi, Huang, Jingying, Chen, Youchun, Huang, Shuxin, Yao, Danlin, Xu, Ling, Lu, Yuhong, Chen, Shaohua, Li, Yangqiu
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020501/
https://ncbi.nlm.nih.gov/pubmed/32082573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-020-0185-8
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