The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory mechanism involving direct binding between tail and motor domains and its fundamental role in mi...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:eLife
Κύριοι συγγραφείς: Bodrug, Tatyana, Wilson-Kubalek, Elizabeth M, Nithianantham, Stanley, Thompson, Alex F, Alfieri, April, Gaska, Ignas, Major, Jennifer, Debs, Garrett, Inagaki, Sayaka, Gutierrez, Pedro, Gheber, Larisa, McKenney, Richard J, Sindelar, Charles Vaughn, Milligan, Ronald, Stumpff, Jason, Rosenfeld, Steven S, Forth, Scott T, Al-Bassam, Jawdat
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: eLife Sciences Publications, Ltd 2020
Θέματα:
Cell Biology
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015671/
https://ncbi.nlm.nih.gov/pubmed/31958056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51131
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