The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory mechanism involving direct binding between tail and motor domains and its fundamental role in mi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Bodrug, Tatyana, Wilson-Kubalek, Elizabeth M, Nithianantham, Stanley, Thompson, Alex F, Alfieri, April, Gaska, Ignas, Major, Jennifer, Debs, Garrett, Inagaki, Sayaka, Gutierrez, Pedro, Gheber, Larisa, McKenney, Richard J, Sindelar, Charles Vaughn, Milligan, Ronald, Stumpff, Jason, Rosenfeld, Steven S, Forth, Scott T, Al-Bassam, Jawdat
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015671/
https://ncbi.nlm.nih.gov/pubmed/31958056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51131
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