Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies

The selective inhibitor of nuclear export (SINE) compounds selinexor (KPT-330) and eltanexor (KPT-8602) are from a novel class of small molecules that target exportin-1 (XPO1 [CRM1]), an essential nucleo-cytoplasmic transport protein responsible for the nuclear export of major tumor suppressor prote...

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Publicado no:Blood Adv
Main Authors: Fischer, Melissa A., Friedlander, Sharon Y., Arrate, Maria P., Chang, Hua, Gorska, Agnieszka E., Fuller, Londa D., Ramsey, Haley E., Kashyap, Trinayan, Argueta, Christian, Debler, Sophie, Byrne, Michael, Villaume, Matthew T., Shaver, Aaron C., Senapedis, William, Landesman, Yosef, Baloglu, Erkan, Shacham, Sharon, Savona, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013257/
https://ncbi.nlm.nih.gov/pubmed/32045477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000359
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