Propranolol is a mechanism‐based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6‐transgenic mice: Effects on activity and drug responses

BACKGROUND AND PURPOSE: Genetics and drug interactions contribute to large interindividual variation in human CYP2D6 activity. Here, we have characterized propranolol inhibition of human and mouse CYP2D using transgenic (TG) mice, which express both mouse CYP2D and human CYP2D6, and wild‐type (WT) m...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Tolledo, Edgor Cole, Miksys, Sharon, Gonzalez, Frank J., Tyndale, Rachel F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2020
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012948/
https://ncbi.nlm.nih.gov/pubmed/31648367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14884
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