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Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein
1. CYP2B6 is a drug-metabolizing enzyme expressed in the liver and brain that can metabolize bupropion (Zyban®, a smoking cessation drug), activate tobacco-smoke nitrosamines, and inactivate nicotine. Hepatic CYP2B6 is induced by phenobarbital and induction may affect in vivo nicotine disposition, w...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2006
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1617079/ https://ncbi.nlm.nih.gov/pubmed/16751792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706787 |
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